dGH SCREEN Service

Cover Every Unique Sequence

Product Description

dGH SCREEN is a single cell assay designed to monitor structural variants throughout the genome in an entirely de novo fashion. It utilize KromaTiD’s single stranded, synthetic probes to cover every unique sequence in the genome for the ultimate unbiased assessment of potentially causative structural variants. By spanning entire chromosomes, dGH SCREEN enables researchers to directly visualize structural rearrangements anywhere in the genome, making it possible to discover previously unseen or unsuspected rearrangements without knowing where to look in the first place.

With dGH SCREEN, researchers are able to track and localize a wide variety of chromosomal rearrangements within a 10 kb limit of detection:

• Exchange events including reciprocal, balanced and allelic translocations
• Orientation events including inversions, recombination and sister chromatid exchanges
• Chromosomal gain & loss events including sister chromatid fusions, dicentrics/acentrics, fragmentation/chromothripsis, polyploidy, aneuploidy, monosomy, polysomy.

With dGH SCREEN you get:

• Unbiased, single cell, high-resolution whole-genome stability analysis.
• A true profile of structural heterogeneity throughout your edited cells populations.
• An efficient measure of stability of your clones and cell lines.

Performance Data

Chromosome Abberation Data

_{Table 1: Structural Event Summary}

_{Table 2: Distribution of Events by Chromosome}