Recombinant Human CCL14a/HCC-1 Protein(Sumo Tag)
| Specifications | |
|---|---|
| Molecular Weight: | 20 kDa |
| Tag: | N-Sumo |
| Source: | E.coli |
| Purity: | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin Level: | < 10 EU per mg of the protein as determined by the LAL method |
| Format: | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Additional Information | |
|---|---|
| Synonyms: | CCL, HCC-1/HCC, SCYA, Chemokine CC-1/CC, C-C motif chemokine 14, CC-1, CC-3, Chemokine CC-1/CC-3, HCC-1, HCC-1(1-74), HCC-1/HCC-3, HCC-3, NCC-2, Small-inducible cytokine A14, NCC2, SCYA14, CCL14, CKb1, MCIF, SCYL2 |
| Organism: | Human |
| Accn. No.: | Q16627 |
Sequence Information
Gly28-Asn93
Background
CCL14a/HCC-1 has an important biological role in other mammals by evolving under positive selection that has been lost in Ochotonidae (subgenera Pika and Lagotona). CC chemokine ligand 14, CCL14a/HCC-1, is a human CC chemokine that is of recent interest because of its natural ability, upon proteolytic processing of the first eight NH2-terminal residues, to bind to and signal throμgh the human immunodeficiency virus type-1 (HIV-1) co-receptor, CC chemokine receptor 5 (CCR5). Embryo implantation is a complex process involving blastocyst attachment to the endometrial epithelium and subsequent trophoblast invasion of the decidua. We have previously shown that the chemokines CX3CL1 and CCL14a/HCC-1 are abundant in endometrial vasculature, epithelial, and decidual cells at this time, and that their receptors, CX3CR1 and CCR1, are present on invading human trophoblasts. CX3CL1 and CCL14a/HCC-1 promote trophoblast migration.
Price
776,00 €
