Human PDE4A Protein, His Tag (MALS verified)
| Specifications | |
|---|---|
| Category: | Other Recombinant Proteins |
| Molecular Weight: | 47.1 kDa |
| Tag: | C-10×His |
| Label / Conjugate: | N/A |
| Source: | Human PDE4A Protein, His Tag (PDA-H55H3) is expressed from Baculovirus-Insect cells. It contains AA Pro 331 - Met 723 (Accession # P27815-1). |
| Purity: | 90% |
| Endotoxin Level: | 1.0 EU per μg |
| Format: | Liquid |
| Additional Information | |
|---|---|
| Organism: | Human |
| Accn. No.: | P27815-1 |
Sequence Information
Pro 331 - Met 723
Background
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (PDE4A) is an enzyme that in humans is encoded by the PDE4A gene. It belongs to the PDE family who hydrolyze 3′-5′-cyclic adenosine monophosphate (cyclic AMP) to 5′-adenosine monophosphate (AMP). PDE enzyme family plays a pivotal role in regulating levels of the second messenger cAMP. Consequently, PDE4 inhibitors have been investigated as a therapeutic strategy to enhance cAMP signaling in a broad range of diseases, including several types of cancers, as well as in various neurologic, dermatological, and inflammatory diseases.
Price
614,00 €
