SARS-CoV-2 ORF8 Protein, His Tag
| Specifications | |
|---|---|
| Category: | Viral Proteins |
| Molecular Weight: | 14.3 kDa |
| Tag: | C-10×His |
| Label / Conjugate: | N/A |
| Source: | SARS-CoV-2 ORF8 Protein, His Tag (OR8-C52H1) is expressed from human 293 cells (HEK293). It contains AA Phe 16 - Ile 121 (Accession # P0DTC8-1). |
| Purity: | 90% |
| Endotoxin Level: | 1.0 EU per μg |
| Format: | Powder |
| Additional Information | |
|---|---|
| Synonyms: | ORF8 |
| Organism: | SARS-CoV-2 |
| Accn. No.: | P0DTC8-1 |
Sequence Information
Phe 16 - Ile 121
Background
The viral protein encoded by open reading frame 8 (ORF8) of SARS-CoV-2, which shares the least homology with SARS-CoV among all viral proteins, directly interacts with MHC-Ι molecules and mediates their down-regulation. In ORF8-expressing cells, MHC-Ι molecules are selectively targeted for lysosomal degradation via autophagy. Thus, SARS-CoV-2–infected cells are much less sensitive to lysis by cytotoxic T lymphocytes.
Price
559,00 €
