Human Osteopontin (OPN) Protein
| Specifications | |
|---|---|
| Category: | Other Recombinant Proteins |
| Molecular Weight: | 33.0 kDa |
| Tag: | C-6×His |
| Label / Conjugate: | N/A |
| Source: | Human Osteopontin, His Tag (OPN-H5227) is expressed from human 293 cells (HEK293). It contains AA Ile 17 - Asn 300 (Accession # AAH07016). |
| Purity: | 90% |
| Endotoxin Level: | 0.1 EU per μg |
| Format: | Powder |
| Additional Information | |
|---|---|
| Synonyms: | SPP1,BNSP,OPN,Uropontin,Nephropontin,Osteopontin,BSP-1,ETA-1,BSPI |
| Organism: | Human |
| Accn. No.: | P10451 |
Sequence Information
Ile 17 - Asn 300
Background
Osteopontin (OPN) is also known as Secreted phosphoprotein 1 (SPP1), Bone sialoprotein 1, Nephropontin, Urinary stone protein, Uropontin, BNSP, which belongs to the osteopontin family. OPN / SPP1 is a highly negatively charged, extracellular matrix protein that lacks an extensive secondary structure. Full length OPN (OPN-FL) can be modified by thrombin cleavage, which exposes a cryptic sequence, SVVYGLR on the cleaved form of the protein known as OPN-R. Osteopontin / SPP-1 is biosynthesized by a variety of tissue types. OPN is the ligand for integrin alpha-V/beta-3. OPN / SPP1 binds tightly to hydroxyapatite and appears to form an integral part of the mineralized matrix. OPN / SPP1 probably important to cell-matrix interaction. OPN / SPP1 acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.
Price
1.789,00 €
