SARS-CoV-2 Nucleocapsid protein (T205I), His Tag
| Specifications | |
|---|---|
| Category: | Viral Proteins |
| Molecular Weight: | 47.3 kDa |
| Tag: | C-6×His |
| Label / Conjugate: | N/A |
| Source: | SARS-CoV-2 Nucleocapsid protein (T205I), His Tag (NUN-C52Hd) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 419 (Accession # QHO62115.1 (T205I)). The nucleocapsid protein is consisted of the N-terminal RNA-binding domain (NTD) and the C-terminal dimerization domain (CTD), divided by a central serine/arginine-rich (SR)-linker responsible for phosphorylation. The mutation T205I was identified in the SARS-CoV-2 Beta (Pango Lineage: B.1.351) and Mu (Pango Lineage: B.1.621) variants (data retrieved from https://pubmed.ncbi.nlm.nih.gov/33095454/). |
| Purity: | 90% |
| Endotoxin Level: | 1.0 EU per μg |
| Format: | Powder |
| Additional Information | |
|---|---|
| Synonyms: | Nucleocapsid protein,NP,Protein N |
| Organism: | SARS-CoV-2 |
Sequence Information
Met 1 - Ala 419
Background
Nucleocapsid (N) protein is the most abundant protein found in coronavirus. CoV N protein is a highly immunogenic phosphoprotein important for viral genome replication and modulation of cell signaling pathways. It was first identified by a research team while they were screening for ADP-ribosylated proteins during coronavirus (CoV) infection (Grunewald M. E., et al. 2017, Virology; 517: 62-68). The array of diverse functional activities accommodated in N protein makes it more than a structural protein but also an interesting target in the development of antiviral therapeutics. Because of the conservation of N protein sequence and its strong immunogenicity, N protein of coronavirus is chosen as a diagnostic tool.
Price
3.779,00 €
