SARS-CoV-2 (COVID-19) NSP1 Protein, His Tag
| Specifications | |
|---|---|
| Category: | Viral Proteins |
| Molecular Weight: | 21.7 kDa |
| Tag: | C-10×His |
| Label / Conjugate: | N/A |
| Source: | SARS-CoV-2 NSP1, His Tag (NS1-C51H7) is expressed from E. coli cells. It contains AA Met 1 - Gly 180 (Accession # YP_009725297.1). |
| Purity: | 90% |
| Endotoxin Level: | 1.0 EU per μg |
| Format: | Powder |
| Additional Information | |
|---|---|
| Synonyms: | NSP1,nsp1,Leader protein,Host translation inhibitor nsp1 |
| Organism: | SARS-CoV-2 |
Sequence Information
Met 1 - Gly 180
Background
The viral nonstructural protein 1 (nsP1) is the only membrane-associated protein that anchors the replication complex to the cellular membranes. NSP1 inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.
Price
559,00 €
