Human NOTCH3 Protein, Fc Tag
| Specifications | |
|---|---|
| Category: | Other Recombinant Proteins |
| Molecular Weight: | 71.4 kDa |
| Tag: | C-Fc |
| Label / Conjugate: | N/A |
| Source: | Human NOTCH3, Fc Tag (NO3-H5255) is expressed from human 293 cells (HEK293). It contains AA Ala 40 - Glu 467 (Accession # Q9UM47-1). |
| Purity: | 95% |
| Endotoxin Level: | 1.0 EU per μg |
| Format: | Powder |
| Additional Information | |
|---|---|
| Synonyms: | Notch-3,NOTCH3 |
| Organism: | Human |
| Accn. No.: | Q9UM47-1 |
Sequence Information
Ala 40 - Glu 467
Background
Notch3 is one of four mammalian Notch proteins, which act as signalling receptors and involve in developmental patterning, cell fate decisions, regulation of cell survival and proliferation. Notch3 could interact with membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Via ligand activation, notch intracellular domain (NICD) is released and forms a transcriptional activator RBPJ/RBPSUH complex, which activates genes of the enhancer of split locus. Consequently, the activation of Notch3 can lead to the implementation of differentiation, proliferation and apoptotic programs
Price
3.365,00 €
