Human NOTCH2 Protein, Fc Tag (MALS verified)
| Specifications | |
|---|---|
| Category: | Other Recombinant Proteins |
| Molecular Weight: | 80.5 kDa |
| Tag: | C-Fc |
| Label / Conjugate: | N/A |
| Source: | Human NOTCH2, Fc Tag (NO2-H5255) is expressed from human 293 cells (HEK293). It contains AA Leu 26 - Gln 530 (Accession # Q04721-1). |
| Purity: | 95% |
| Endotoxin Level: | 1.0 EU per μg |
| Format: | Powder |
| Additional Information | |
|---|---|
| Synonyms: | NOTCH2,hN2,N2ECD |
| Organism: | Human |
| Accn. No.: | Q04721-1 |
Sequence Information
Leu 26 - Gln 530
Background
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus . Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation . Positively regulates self-renewal of liver cancer cells .
Price
3.365,00 €
