Human NKG2D / CD314 Protein, His Tag
| Specifications | |
|---|---|
| Category: | Other Recombinant Proteins |
| Molecular Weight: | 18.5 kDa |
| Tag: | N-10×His |
| Label / Conjugate: | N/A |
| Source: | Human NKG2D, His Tag (NKD-H5245) is expressed from human 293 cells (HEK293). It contains AA Ile 73 - Val 216 (Accession # P26718-1). |
| Purity: | 90% |
| Endotoxin Level: | 1.0 EU per μg |
| Format: | Powder |
| Additional Information | |
|---|---|
| Synonyms: | NKG2D,CD314,KLRK1,NK cell receptor D |
| Organism: | Human |
| Accn. No.: | P26718-1 |
Sequence Information
Ile 73 - Val 216
Background
NKG2D is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors, also known as KLRK1, CD314, D12S2489E, KLR and killer cell lectin like receptor K1. NKG2D itself forms a homodimer whose ectodomains serve for ligand binding. NKG2D is a major recognition receptor for the detection and elimination of transformed and infected cells as its ligands are induced during cellular stress, either as a result of infection or genomic stress such as in cancer. In NK cells, NKG2D serves as an activating receptor, which itself is able to trigger cytotoxicity. The function of NKG2D on CD8+ T cells is to send co-stimulatory signals to activate them.
Price
456,00 €
