Human Nectin-4 Protein, Fc Tag
| Specifications | |
|---|---|
| Category: | Immune Checkpoint Proteins |
| Molecular Weight: | 60.5 kDa |
| Tag: | C-Fc |
| Label / Conjugate: | N/A |
| Source: | Human Nectin-4, Fc Tag (NE4-H5255) is expressed from human 293 cells (HEK293). It contains AA Gly 32 - Ser 349 (Accession # Q96NY8-1). |
| Purity: | 95% |
| Endotoxin Level: | 0.1 EU per μg |
| Format: | Powder |
| Additional Information | |
|---|---|
| Synonyms: | NECTIN4,LNIR, PRR4, PVRL4 |
| Organism: | Human |
| Accn. No.: | Q96NY8-1 |
Sequence Information
Gly 32 - Ser 349
Background
Nectin-4 (gene name PVRL4, poliovirus receptor-like 4) is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. Nectins are cell adhesion molecules that play a key role in various biological processes such as polarity, proliferation, differentiation and migration, for epithelial, endothelial, immune and neuronal cells, during development and adult life. Nectin-4 is a tumor-associated antigen in 50%, 49% and 86%o of breast, ovarian and lung carcinomas, respectively, mostly on tumors of bad prognosis. Its expression is not detected in the corresponding normal tissues.
Price
3.365,00 €
