Human Mucin-1 / MUC-1 (24-380) Protein, His Tag (MALS verified)
| Specifications | |
|---|---|
| Category: | Bio-Markers & CD Antigens |
| Molecular Weight: | 35.6 kDa |
| Tag: | C-10×His |
| Label / Conjugate: | N/A |
| Source: | Human Mucin-1 (24-380) Protein, His Tag (MU1-H52H7) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Ser 380 (Accession # P15941-1). |
| Purity: | 95% |
| Endotoxin Level: | 1.0 EU per μg |
| Format: | Powder |
| Additional Information | |
|---|---|
| Organism: | Human |
| Accn. No.: | P15941-1 |
Sequence Information
Ser 24 - Ser 380
Background
Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction. MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. Probably plays a role in maintaining homeostasis on mucosal surfaces.
Price
505,00 €
