Rat Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His Tag&Tag Free
| Specifications | |
|---|---|
| Category: | Bio-Markers & CD Antigens |
| Molecular Weight: | 112.3 kDa | 81.7 kDa |
| Tag: | C-10×His | Native |
| Label / Conjugate: | N/A |
| Source: | Rat ITGAV&ITGB5 Heterodimer, His Tag&Tag Free (IT5-R52E3) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Pro 988 (ITGAM) & Leu 25 - Asn 719 (ITGB5) (Accession # NP_001385621.1 (ITGAM) & NP_671480.2 (ITGB5)). |
| Purity: | 90% |
| Endotoxin Level: | 1.0 EU per μg |
| Format: | Powder |
| Additional Information | |
|---|---|
| Synonyms: | Integrin alpha V beta 5,ITGAV&ITGB5 |
| Organism: | Rat |
| Accn. No.: | NP_001385621.1 |
Sequence Information
Phe 31 - Pro 988 (ITGAM) & Leu 25 - Asn 719 (ITGB5)
Background
Integrin alpha V beta 5 (ITGAV & ITGB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAV & ITGB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAV & ITGB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency.
Price
3.753,00 €
