Human Integrin alpha 2 beta 1 (ITGA2 & ITGB1) Heterodimer Protein
| Specifications | |
|---|---|
| Category: | Bio-Markers & CD Antigens |
| Molecular Weight: | 127.6 kDa (ITGA2) & 83.7 kDa (ITGB1) |
| Tag: | C-10×His | Native |
| Label / Conjugate: | N/A |
| Source: | Human ITGA2&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-H52W6) is expressed from human 293 cells (HEK293). It contains AA Tyr 30 - Thr 1132 (ITGA2) & Gln 21 - Asp 728 (ITGB1) (Accession # P17301-1 (E534K) (ITGA2) & P05556-1 (ITGB1)). |
| Purity: | 95% |
| Endotoxin Level: | 1.0 EU per μg |
| Format: | Powder |
| Additional Information | |
|---|---|
| Synonyms: | Integrin alpha 2 beta 1,ITGA2 & ITGB1 |
| Organism: | Human |
| Accn. No.: | P17301-1 |
Sequence Information
Tyr 30 - Thr 1132 (ITGA2) & Gln 21 - Asp 728 (ITGB1)
Background
Integrin alpha 2 beta 1 is one of twelve integrin family adhesion receptors that share the beta 1 subunit. It is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A and Human echoviruses 1 and 8. DGEA inhibited rotavirus binding to alpha2beta1 and infectivity. In a novel process, integrin-using viruses bind the alpha2 I domain of alpha2beta1 via DGE in VP4 and interact with alphaXbeta2 (via GPR) and alphaVbeta3 by using VP7 to facilitate cell entry and infection.
Price
582,00 €
