Human GITR Ligand / TNFSF18 Protein, His Tag, active trimer (MALS verified)
| Specifications | |
|---|---|
| Molecular Weight: | 46.6 kDa |
| Tag: | N-10×His |
| Source: | Human GITR Ligand Protein, His Tag, active trimer (GIL-H524a) is expressed from human 293 cells (HEK293). It contains AA Gln 50 - Ser 177 (Accession # AAH69319.1). |
| Purity: | 90% |
| Endotoxin Level: | 1.0 EU per μg |
| Format: | Powder |
| Additional Information | |
|---|---|
| Organism: | Human |
| Accn. No.: | AAH69319.1 |
Sequence Information
Gln 50 - Ser 177
Background
Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid - induced TNF-related ligand (GITRL or GITR Ligand), Activation - inducible TNF - related ligand (AITRL), which belongs to the tumor necrosis factor family. TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 / GITRL is up-regulated after stimulation by bacterial lipopolysaccharides (LPS). TNFSF18 Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. TNFSF18 / GITR Ligand is important for interactions between activated T-lymphocytes and endothelial cells. TNFSF18 also mediates activation of NF-kappa-B.
Price
499,00 €
