Anti-MERS-CoV Nucleocapsid Protein Polyclonal Antibody
| Specifications | |
|---|---|
| Type: | Primary Antibody |
| Clonality: | Polyclonal |
| Host: | Rabbit |
| Reactivity: | MERS-CoV |
| Isotype: | IgG |
| Label: | Unconjugated |
| Concentration: | 1mg/mL |
| Buffer: | 0.2 μm filtered solution in PBS |
| Additional Information | |
|---|---|
| Synonyms: | coronavirus NP, coronavirus Nucleocapsid, coronavirus Nucleoprotein, cov np, ncov NP, novel coronavirus Nucleoprotein, NP, Nucleocapsid, Nucleoprotein |
Applications
WB
Recommended Dilution
WB 1:1000-1:5000
Immunogen
A synthetic peptide corresponding to the center region of MERS-CoV (NCoV / Novel coronavirus) Nucleocapsid Protein (NP protein)
Purification/Format
Antigen Affinity
Background
Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.
Price
357,00 €
