Purified Anti-Mouse IL-17A Antibody[17F3]

Specifications
Type:Primary Antibody
Clonality:Monoclonal
Clone Name:17F3
Host:Mouse
Reactivity:Mouse
Isotype:Mouse IgG1, κ
Label:Unconjugated
Concentration:≥1 mg/mL
Buffer:Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300.
Additional Information
Synonyms:Interleukin-17A, Il17a, Ctla9,
Gene Symbol:Il17a
Organism:Mus musculus
Gene ID:16171
UniProt ID:Q62386
Control Antibody:E-AB-F09793A

Applications

ICFCM

Recommended Dilution

Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10^6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Background

The 17F3 monoclonal antibody reacts with mouse IL-17A a 15-20 kDa cytokine expressed by Th17 cells, γδ T cells, iNKT cells, NK cells, LTi cells, neutrophils, and intestinal Paneth cells. IL-17A has pleiotropic effects in immunoregulation and inflammation. It plays an important role in anti-microbial and chronic inflammation by inducing cytokine and chemokine production, neutrophil influx, and the production of antibacterial peptides but it is also an inflammatory mediator in the development of autoimmune diseases including rheumatoid arthritis, asthma, multiple sclerosis, and psoriasis. The 17F3 antibody has been shown to neutralize IL-18A?in vivo.
Price
2.899,00 €
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Dr. Kristin Kördel

Tel. +49 (0) 6221 71415 16

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