NRP1 Expression Lentivector, pCDH-CMV-NRP1-EF1alpha-Neo (Plasmid)

Product Description

Quickly and reliably create cells expressing NRP1 to advance your studies of the protein’s role in SARS-CoV-2 infection and normal physiology

• Leverage SBI’s robust lentivector expression technology to study NRP1
• Choose ready-to-package plasmid or ready-to-transduce virus
• Also available as a stable cell line that expresses both NRP1 and ACE2 for SARS-CoV-2 studies

NRP1 Expression Lentivector is based on the robust pCDH-CMV-MCS-EF1α-Neo Cloning and Expression Lentivector (Cat.# CD514B-1-SBI), and delivers NRP1 expression from the CMV promoter, with a separate EF1α promoter driving the expression of the neomycin resistance gene for selection.

NRP1 is a host factor for SARS-CoV-2 infection that enhances ACE2-mediated cell entry [1, 2], and the NRP1 Expression Lentivector gives you the ability to express NRP1 in the cell line of your choice. Safely study SARS-CoV-2 infection, discover inhibitors, and more.

The NRP1 Expression Lentivector is available in both plasmid and ready-to-transduce pre-packaged lentivirus formats.

References

Cantuti-Castelvetri L, et al. Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science. 2020 Nov 13;370(6518):856-860. PMCID: PMC7857391.

Daly JL, et al. Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science. 2020 Nov 13;370(6518):861-865. PMID: 33082294.