Rat B7-H4 Protein, His Tag
| Specifications | |
|---|---|
| Category: | Immune Checkpoint Proteins |
| Molecular Weight: | 27.1 kDa |
| Tag: | C-10×His |
| Label / Conjugate: | N/A |
| Source: | Rat B7-H4, His Tag (B74-R52H9) is expressed from human 293 cells (HEK293). It contains AA Phe 29 - Gly 257 (Accession # Q501W4-1). |
| Purity: | 90% |
| Endotoxin Level: | 1.0 EU per μg |
| Format: | Powder |
| Additional Information | |
|---|---|
| Synonyms: | B7-H4,VTCN1,B7S1,B7h.5 |
| Organism: | Rat |
| Accn. No.: | Q501W4-1 |
Sequence Information
Phe 29 - Gly 257
Background
V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.
Price
3.365,00 €
