Anti-GNE (C-term) Antibody

WB, FC

This GNE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-67 amino acids from the C-terminal region of human GNE.

GNE is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells.