Chromatin reader proteins bind specific histone modifications and often recruit additional proteins, enzymes, or regulatory complexes. They play vital roles in many disease-relevant pathways and represent key drug targets. EpiCypher offers a variety of recombinant GST-tagged or His-tagged histone binding domains for academic and pharmaceutical research.
Chromatin architecture is composed of a diverse array of histone PTMs, which influence gene expression via the binding activity of various chromatin reader proteins. These proteins contain binding domains that target specific histone PTMs.