shRNA Libraries & Constructs

shRNA libraries for titratable pooled gene knockdown across genome-wide or focused sets

When you want titratable knockdown rather than CRISPR knockout, shRNA libraries deliver pooled hypomorphic knockdown across genome-wide or focused gene sets. The category remains useful where partial knockdown is more informative than knockout or where CRISPR knockout is lethal.

Pick by library scope and inducibility.

1. Library scope. Genome-wide versus focused sub-libraries. Fewer shRNA libraries are commercially available than sgRNA, but the catalogue covers the major modules.
2. Promoter. U6 standard. Tet-on for inducible knockdown.
3. Vector backbone. Lentiviral standard.
4. Knockdown depth. Hypomorphic and titratable, unlike CRISPR null.
5. Off-target risk. Higher than sgRNA. Confirm phenotypes with multiple constructs per gene.

Cellecta supplies shRNA libraries in this inventory.