Yamanaka-factor delivery reagents for reprogramming somatic cells into iPSC lines
When you want to reprogram somatic cells into iPSC, Yamanaka-factor delivery (Oct4, Sox2, Klf4, c-Myc) or alternative factor combinations do it. Delivery format affects integration footprint, reprogramming efficiency, and clinical-translation potential.
Pick by footprint requirement.
- Highest efficiency. Lentiviral. Genomic integration but reliable.
- Footprint-free research lines. Episomal or mRNA reprogramming. Lower efficiency, no integration.
- Footprint-free clinical candidates. Episomal, mRNA, or protein-based reprogramming.
- Starting cell type. Fibroblast standard. PBMC and blood-cell reprogramming becoming more common.
- Confirmation. Characterise pluripotency by multiple methods (marker expression, teratoma or trilineage differentiation, karyotype).
GeneCopoeia leads in reprogramming-factor vectors and reagents in this inventory.
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