Methylated DNA Amplification

Methylation-preserving whole-genome amplification for low-input and single-cell methylation analysis

When you need methylated-DNA whole-genome amplification (WGA) for low-input methylation analysis, this section covers methylation-preserving WGA that retains methylation information through amplification. Useful for single-cell methylation work and forensic DNA methylation.

Pick by chemistry and input.

1. Chemistry. Methylation-preserving WGA versus bisulfite-then-amplify.
2. Input. Some kits accept picogram-scale input from single-cell or scarce samples.
3. Coverage uniformity. Verify against published benchmarks before scaling.
4. Downstream compatibility. For single-cell methylation work the WGA chemistry propagates to the methylome map.
5. Bisulfite compatibility. Confirm downstream bisulfite workflow compatibility.

EpigenTek leads in methylated DNA amplification.