Cell transformation reagents for oncogene delivery and malignant phenotype hallmark assays
When you want to study how primary cells transition to a malignant phenotype, transformation reagents introduce oncogenes (RAS, MYC, large T) and measure transformation hallmarks (anchorage-independent growth, contact inhibition loss, in vivo tumour formation). The category overlaps with cell immortalisation but focuses on transformation-associated phenotypic changes.
Pick by oncogene and delivery.
- Oncogene combination. Single oncogenes for partial transformation. Co-expression of cooperating oncogenes for full transformation. The specific cocktail depends on cell type.
- Delivery. Lentiviral for stable. Transient for short-term phenotype monitoring.
- Phenotype characterisation. Confirm cancer phenotypes (anchorage independence, proliferation, in vivo tumour formation) after introduction. Oncogene expression alone does not equal transformation.
- Validation tools. Use the matched anchorage-independent growth assays and other transformation-specific readouts.
Cell Biolabs supplies transformation assay kits and reagent packages.
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