Natural, synthetic, and hybrid 3D hydrogel systems with tunable stiffness and degradation
When 2D plastic stops modelling the biology you care about, 3D hydrogels suspend cells in a polymer scaffold with tunable stiffness, biofunctionalisation, and degradation. The category includes natural matrices (collagen, fibrin, hyaluronic acid, Matrigel) with native ECM cues, synthetic PEG-based hydrogels with defined chemistry, and hybrid formulations.
Pick by reproducibility and physiological context.
- Reproducibility-critical work. Choose defined synthetic hydrogels (TheWell VitroGel, Cellendes 3D Life). Tunable stiffness, defined biofunctionalisation, predictable batch-to-batch.
- Native ECM context. Choose natural matrices (collagen, Matrigel). Accept higher lot variance for native cues.
- Stiffness. Match kPa to native tissue. Soft for brain or liver, stiffer for cartilage or bone.
- Cell-friendly gelation. Photo-, temperature-, ion-, or click-crosslinked chemistries differ in cell viability during gelation. Match to your cell type.
- Imaging compatibility. Confirm clearing-protocol compatibility before committing.
TheWell supplies VitroGel in this inventory.